The Multidisciplinary Computing Centre (MDC) of the Indian Institute of Space Science and Technology was established to provide various computer solutions for research problems and to facilitate and support the institute's essential teaching and academic goals. The Center aims to become a center of excellence in computational techniques and computer simulations for science and engineering and provide expertise in Big Data Analysis, Climate Modelling, Computational Fluid Dynamics, Computational Structural Mechanics, Computation-Assisted Materials Science, Computer Vision, and Virtual Reality, Machine Learning, Network Science and Engineering, Nonlinear Dynamics, Optimization, Geoinformatics, Monte Carlo Simulations. Three parallel computing clusters run in the Center with a total computational power of 220 teraflops, with parallel file systems. The center has 40 high-end Xeon workstations/servers with multiple configurations. Most workstations have over 128 GB of RAM, sixteen cores, and dedicated GPU cards. The Center has three high-end GPU Servers, three license servers, and storage servers.  Faculty members, Students, and project staff can get access to these systems by applying online.